Yoko Irukayama-Tomobe : rechercher sur Z-Library

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1

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies

Nagase, Hiroshi, Yamamoto, Naoshi, Yata, Masahiro, Ohrui, Sayaka, Okada, Takahiro, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ishikawa, Yukiko, Ogawa, Yasuhiro, Hir

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 1.79 MB

english, 2017

2

Oxygen radicals mediate the final exacerbation of endothelin-1-induced gastric ulcer in rat

Spyridon Lazaratos, Yoko Irukayama-Tomobe, Takashi Miyauchi, Katsutoshi Goto, Akira Nakahara

Journal:

European Journal of Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 312 KB

english, 2001

3

Chronic treatment with probucol effectively inhibits progression of pulmonary hypertension in rats

Yoko Irukayama-Tomobe, Satoshi Sakai, Takashi Miyauchi

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 94 KB

english, 2000

4

Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans

Seiji Maeda, Takashi Miyauchi, Tetsuji Kakiyama, Jun Sugawara, Motoyuki Iemitsu, Yoko Irukayama-Tomobe, Haruka Murakami, Yoshito Kumagai, Shinya Kuno, Mitsuo Matsuda

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 124 KB

english, 2001

5

Association of An Orexin 1 Receptor 408Val Variant with Polydipsia–Hyponatremia in Schizophrenic Subjects

Joanne Meerabux, Yoshimi Iwayama, Takeshi Sakurai, Hisako Ohba, Tomoko Toyota, Kazuo Yamada, Ruby Nagata, Yoko Irukayama-Tomobe, Hiromitsu Shimizu, Kiyoshi Yoshitsugu, Katsuya Ohta, Takeo Yoshikawa

Journal:

Biological Psychiatry

Année:

2005

Langue:

english

Fichier:

PDF, 256 KB

english, 2005

6

Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-b pathway

Takehiro Ogata, Takashi Miyauchi, Satoshi Sakai, Masakatsu Takanashi, Yoko Irukayama-Tomobe, Iwao Yamaguchi

Journal:

Journal of the American College of Cardiology

Année:

2004

Langue:

english

Fichier:

PDF, 302 KB

english, 2004

7

The role of NPBWR1 on autonomic nervous system

Irukayama-Tomobe, Yoko, Murakoshi, Nobuyuki, Sakurai, Takeshi

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 78 KB

english, 2013

8

Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists

Nagahara, Takashi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Kuroda, Daisuke, Gouda, Hiroaki, Kumagai, Hidetoshi, Fujii, Hideaki, Yanagisawa, Masashi, Nagase, Hiros

Journal:

Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 574 KB

english, 2015

9

Activation of Peroxisome Proliferator-activated Receptor-?? Decreases Endothelin-1-induced p38 Mitogen-activated Protein Kinase Activation in Cardiomyocytes

Irukayama-Tomobe, Yoko, Miyauchi, Takashi, Kasuya, Yoshitoshi, Sakai, Satoshi, Goto, Katsutoshi, Yamaguchi, Iwao

Journal:

Journal of Cardiovascular Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 150 KB

english, 2004

10

The Peroxisome Proliferator-activated Receptor ?? Activator Fenofibrate Inhibits Endothelin-1-induced Cardiac Fibroblast Proliferation

Ogata, Takehiro, Miyauchi, Takashi, Irukayama-Tomobe, Yoko, Takanashi, Masakatsu, Goto, Katsutoshi, Yamaguchi, Iwao

Journal:

Journal of Cardiovascular Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 156 KB

english, 2004

11

Effects of Medium-chain Triglyceride (MCT) Application to SHR on Cardiac Function, Hypertrophy and Expression of Endothelin-1 mRNA and other Genes

Shimojo, Nobutake, Miyauchi, Takashi, Iemitsu, Motoyuki, Irukayama-tomobe, Yoko, Maeda, Seiji, Ohkubo, Takeshi, Tanaka, Yukihisa, Goto, Katsutoshi, Yamaguchi, Iwao

Journal:

Journal of Cardiovascular Pharmacology

Année:

2004

Langue:

english

Fichier:

PDF, 105 KB

english, 2004

12

Peroxisome proliferator-activated receptor-γ activators inhibit endothelin-1-related cardiac hypertrophy in rats

SAKAI, Satoshi, MIYAUCHI, Takashi, IRUKAYAMA-TOMOBE, Yoko, OGATA, Takehiro, GOTO, Katsutoshi, YAMAGUCHI, Iwao

Journal:

Clinical Science

Année:

2002

Langue:

english

Fichier:

PDF, 92 KB

english, 2002

13

Stimulation of peroxisome-proliferator-activated receptor α (PPAR α) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts

OGATA, Takehiro, MIYAUCHI, Takashi, SAKAI, Satoshi, IRUKAYAMA-TOMOBE, Yoko, GOTO, Katsutoshi, YAMAGUCHI, Iwao

Journal:

Clinical Science

Année:

2002

Langue:

english

Fichier:

PDF, 157 KB

english, 2002

14

Effects of aging and subsequent exercise training on gene expression of endothelin-1 in rat heart

IEMITSU, Motoyuki, MIYAUCHI, Takashi, MAEDA, Seiji, TANABE, Takumi, IRUKAYAMA-TOMOBE, Yoko, GOTO, Katsutoshi, MATSUDA, Mitsuo, YAMAGUCHI, Iwao

Journal:

Clinical Science

Année:

2002

Langue:

english

Fichier:

PDF, 133 KB

english, 2002

15

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Tominaga, Hiromu, Ishikawa, Yukiko, Hosokawa, Naoto, Ambai, Shinobu, Kawabe, Yuki, Uchida, Shuntaro, Nakajima, Ryo, Saitoh, Tsuyoshi, Kanda, Takeshi, Vogt, Kas

Journal:

Proceedings of the National Academy of Sciences

Année:

2017

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2017

16

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor

Yamamoto, Naoshi, Ohrui, Sayaka, Okada, Takahiro, Yata, Masahiro, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hay

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2017

17

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity

Ohrui, Sayaka, Yamamoto, Naoshi, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, Gouda, Hiroaki, Ya

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 500 KB

english, 2017

18

Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice

Saitoh, Akiyoshi, Tominaga, Hiromu, Ogawa, Yasuhiro, Irukayama-Tomobe, Yoko, Yamada, Mitsuhiko, Yanagisawa, Masashi, Nagase, Hiroshi

Journal:

Pharmacological Reports

Année:

2017

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2017

19

A Single Nucleotide Polymorphism of the Neuropeptide B/W Receptor-1 Gene Influences the Evaluation of Facial Expressions

Watanabe, Noriya, Wada, Mari, Irukayama-Tomobe, Yoko, Ogata, Yousuke, Tsujino, Natsuko, Suzuki, Mika, Furutani, Naoki, Sakurai, Takeshi, Yamamoto, Miyuki, Roman, Gregg

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 405 KB

english, 2012

20

Aging-induced decrease in the PPAR-α level in hearts is improved by exercise training

Iemitsu, Motoyuki, Miyauchi, Takashi, Maeda, Seiji, Tanabe, Takumi, Takanashi, Masakatsu, Irukayama-Tomobe, Yoko, Sakai, Satoshi, Ohmori, Hajime, Matsuda, Mitsuo, Yamaguchi, Iwao

Journal:

American journal of physiology. Heart and circulatory physiology

Année:

2002

Fichier:

PDF, 437 KB

2002

21

Aging-induced decrease in the PPAR-α level in hearts is improved by exercise training

Iemitsu, Motoyuki, Miyauchi, Takashi, Maeda, Seiji, Tanabe, Takumi, Takanashi, Masakatsu, Irukayama-Tomobe, Yoko, Sakai, Satoshi, Ohmori, Hajime, Matsuda, Mitsuo, Yamaguchi, Iwao

Journal:

American journal of physiology. Heart and circulatory physiology

Année:

2002

Langue:

english

Fichier:

PDF, 437 KB

english, 2002

22

Essential structure of orexin 1 receptor antagonist YNT-707, Part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

Yamamoto, Naoshi, Ohrui, Sayaka, Okada, Takahiro, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, G

Journal:

Bioorganic & Medicinal Chemistry

Année:

2019

Fichier:

PDF, 1.00 MB

2019

23

Essential structure of orexin 1 receptor antagonist YNT-707, Part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring

Yamamoto, Naoshi, Ohrui, Sayaka, Okada, Takahiro, Saitoh, Tsuyoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Watanabe, Yurie, Hayakawa, Daichi, G

Journal:

Bioorganic & Medicinal Chemistry

Année:

2019

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2019

24

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group

Saitoh, Tsuyoshi, Seki, Kazunori, Nakajima, Ryo, Yamamoto, Naoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Yanagisawa, Masashi, Nagase, Hiroshi

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2020

Fichier:

PDF, 529 KB

2020

25

Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine

Nagumo, Yasuyuki, Katoh, Koki, Iio, Keita, Saitoh, Tsuyoshi, Kutsumura, Noriki, Yamamoto, Naoshi, Ishikawa, Yukiko, Irukayama-Tomobe, Yoko, Ogawa, Yoshihiro, Baba, Takeshi, Tanimura, Ryuji, Yanagisawa

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2020

Fichier:

PDF, 977 KB

2020